Inzitizi nini ya glycocalyx ifasha kanseri kwirinda ubudahangarwa bw'umubiri

Bumwe mu buryo ingirabuzimafatizo za kanseri zihisha ubudahangarwa bw'umubiri ni ugukora inzitizi yoroheje yitwa glycocalyx. Mu bushakashatsi bushya, abashakashatsi basuzumye imiterere y’iyi nzitizi bakoresheje imyanzuro itigeze ibaho, bavumbuye amakuru ashobora gufasha kunoza ubudahangarwa bwa kanseri ya selile.
Uturemangingo twa kanseri dukunze gukora glycocalyx ifite urusenda rwinshi rwo hejuru rw'utugingo ngengabuzima, bikekwa ko bifasha kurinda kanseri kanseri kwibasirwa na selile. Nyamara, gusobanukirwa kumubiri kuriyi nzitizi bikomeje kuba bike, cyane cyane kubijyanye na kanseri yubudahangarwa bwa kanseri, bikubiyemo kuvana umurwayi ingirabuzimafatizo, kubihindura kugirango bishakire kandi bisenye kanseri, hanyuma babisubize mubarwayi.
Sangwu Park, umunyeshuri wahawe impamyabumenyi muri laboratoire ya Matayo Paszek muri kaminuza ya Cornell muri ISAB, muri New York yagize ati: "Twabonye ko impinduka mu bunini bwa barrière ntoya nka nanometero 10 zigira ingaruka ku gikorwa cyo kurwanya antitumor z'uturemangingo tw’umubiri cyangwa ingirabuzimafatizo zakozwe na immunotherapy". Ati: “Twifashishije aya makuru mu gukora ingirabuzimafatizo zishobora kunyura muri glycocalyx, kandi turizera ko ubu buryo bwakoreshwa mu kunoza ubudahangarwa bw'umubiri bugezweho.” Ibinyabuzima.
Park yagize ati: "Laboratwari yacu yazanye ingamba zikomeye zitwa scanning angle interference microscopie (SAIM) yo gupima glycocalyx ya nanosize ya kanseri ya kanseri". Ati: “Ubu buryo bwo gufata amashusho bwadushoboje gusobanukirwa isano iri hagati ya kanseri ifitanye isano na kanseri hamwe na biofiziki ya glycocalyx.”
Abashakashatsi bakoze moderi ya selile kugirango bagenzure neza imvugo yimitsi yo hejuru yigana glycocalyx ya selile kanseri. Bahise bahuza SAIM nuburyo bwa genetike kugirango bakore iperereza ryukuntu ubucucike bwubuso, glycosylation, hamwe no guhuza imisemburo ifitanye isano na kanseri bigira ingaruka kumubyimba wa nanoscale. Basesenguye kandi uko umubyimba wa glycocalyx ugira ingaruka ku kurwanya ingirabuzimafatizo ziterwa na selile.
Ubushakashatsi bwerekana ko umubyimba wa kanseri ya kanseri glycocalyx ari kimwe mu bipimo nyamukuru bigena kwirinda ingirabuzimafatizo, kandi ko ingirabuzimafatizo z'umubiri zikora neza niba glycocalyx ari nto.
Hashingiwe kuri ubu bumenyi, abashakashatsi bakoze ingirabuzimafatizo zifite imisemburo idasanzwe ku buso bwabo butuma bahuza kandi bagakorana na glycocalyx. Ubushakashatsi ku rwego rwa selile bwerekanye ko uturemangingo tw’umubiri dushobora gutsinda intwaro za glycocalyx ya selile.
Abashakashatsi noneho barateganya kumenya niba ibisubizo bishobora kwigana muri laboratoire hanyuma amaherezo bikageragezwa.
Parike ya Sangwoo izerekana ubu bushakashatsi (incamake) mugihe cya "Glycosylation Regulatory in the Spotlight" ku cyumweru, tariki ya 26 Werurwe, 2-3h00 PT, Seattle Convention Centre, icyumba 608. Menyesha itsinda ryitangazamakuru kugirango umenye amakuru menshi cyangwa unyuze kubuntu kuri nama.
Nancy D. Lamontagne ni umwanditsi wa siyansi akaba n'umwanditsi muri Creative Science Writing i Chapel Hill, muri Karoline y'Amajyaruguru.
Injira aderesi imeri hanyuma tuzaguhereza ingingo ziheruka, kubazwa nibindi buri cyumweru.
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Ubusobanuro bwibanze "barcode". Gukuraho poroteyine nshya mu ndwara zo mu bwonko. Molekile zingenzi za lipid igitonyanga catabolism. Soma ingingo ziheruka kuriyi ngingo.